VEGF和nm23在甲状腺乳头状癌中的表达及其病理意义.doc

文档介绍：VEGF和nm23在甲状腺乳头状癌中的表达及其病理意义
(作者:___________单位: ___________邮编: ___________)
【摘要】目的探讨VEGF和nm23在甲状腺乳头状癌中的表达和临床病理意义。方法采用免疫组织化学方法检测48例甲状腺乳头状癌标本和10例正常甲状腺组织中VEGF和nm23的表达情况。结果甲状腺乳头状癌中存在VEGF和nm23的过度表达;VEGF表达阳性率与甲状腺乳头状癌淋巴结转移呈正相关(P<);nm23表达阳性率与甲状腺乳头状癌淋巴结转移呈负相关(P<)。结论 VEGF和nm23 的表达与甲状腺乳头状癌的侵袭转移密切相关。
【关键词】 VEGF nm23 甲状腺乳头状癌淋巴结转移免疫组织化学
【Abstract】 Objective To investigate the expressions of vascular endothelial growth factor (VEGF), nm23 in thyroid papillary carcinoma(TPC) and their correlation with metastasis. Methods The clinical data of 48 cases of TPC were collected. 10 specimens of normal thyroid tissue served as controls. The expressions of VEGF and nm23 in TPC tissues and normal thyroid tissue were detected by immunohistochemistry. Results VEGF and nm23 were over-expressed in TPC. The lymphaden metastasis of TPC was positively correlated with the positive rate of VEGF (P<), and negatively correlated with nm23(P<). Conclusion The expressions of VEGF and nm23 are significantly correlated to lymphaden metastasis in TPC.
【Key words】 Thyroid papillary carcinoma VEGF nm23 lymphaden metastasis immunohistochemistry.
甲状腺乳头状癌是甲状腺癌中最常见的类型,约占甲状腺癌的70%~80%,有较高的局部侵袭性和颈部淋巴结转移率。本研究应用免疫组织化学方法检测48例甲状腺乳头状癌组织中血管内皮生长因子(VEGF)和nm23蛋白表达情况,探讨其与甲状腺乳头状癌侵袭、淋巴结转移的关系。
1 材料与方法
材料
收集本院2001年1月至2005年12月资料完整的48例甲状腺乳头状癌根治术组织标本,术前均未行放疗、化疗。男11例,女37例,年龄7~78岁()。伴有淋巴结转移15例,无淋巴结转移33例。