文档介绍：X线下可显影的软腭植入材料
(作者:___________单位: ___________邮编: ___________)
作者:张天翔,汪建,陈亮,付晓燕
【摘要】探讨一种X线下可显影的新型软腭植入材料治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的可行性。在自行研制的羟基磷灰石-聚乳酸-三亚甲基碳酸酯(HA-P)软腭植入材料中掺入适量硫酸钡(BaSO4),并将其植入到实验动物体内,定期行X线摄片。这种软腭植入材料性质稳定,材料植入动物体内后,无明显炎症反应,未出现可见降解,并且在长期植入过程中持续保持良好的显影效果,材料间显影清晰。由于此材料的可显影性,便于进行术后复查,判断植入材料的位置、材料是否脱出,同时不改变HA-P材料良好的生物相容性。
【关键词】睡眠呼吸暂停低通气综合征;阻塞性;软腭植入;羟基磷灰石;聚乳酸;X线510182)
Abstract:To investigate the developing effect under X-ray of a new polymer palatal implants material used in treatment of obstructive sleep apnea-hypopnea syndrome(OSAHS).The cylindrical palatal implant was made of Hydroxyapatite and Poly(lactide-co-trimethylene carbonate) (HA-P), adding barium sulphate(BaSO4),to be implanted in vivo. This palatal implants material could be displayed clearly under X-ray. During the experiment, there are not obvious of the visualizing characteristic of the palatal implants material, it is convenient to check the position and degradation degree of the material after surgery and it has good patibility.
Key words:Sleep apnea-hypopnea syndrome; Obstructive; Palatal implant; Hydroxyapatite; Polylactide-co-trimethylene carbonate;X-ray
1 引言
阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome, OSAHS)是临床常见病,其治疗手段日渐增多。软腭植入(PillarTM palatal implants )即是近年提出的一种治疗鼾症及轻、中度OSAHS的新型技术,其高效、微创的优势得到了大量临床研究的支持[1-6]。然而,当前临床应用的软腭植入材料聚对苯二甲酸乙二醇酯(polyethylene te