文档介绍：β2微球蛋白在糖尿病肾病诊断中的价值
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【摘要】目的探讨血清β2微球蛋白(β2MG)和尿β2微球蛋白与2型糖尿病肾病的关系。方法采用免疫比浊法检测98例2型糖尿病患者和对照组38名健康者血清和尿β2MG,在98例糖尿病患者中早期糖尿病肾病50例(DN组),糖尿病未出现肾损害48例(NDN组)。结果糖尿病肾病组血清和尿β2MG与对照组之间差别均有统计学意义(),糖尿病未出现肾损害组与对照组相比,血清β2微球蛋白差别没有统计学意义(),尿β2微球蛋白差别具有统计学意义()。结论检测血清和尿β2微球蛋白早期诊断糖尿病肾病有良好的诊断价值。
【关键词】β2微球蛋白;糖尿病肾病;血清;尿
Abstract: Objective To explore the correlation between serumal and urinary β2microglobulin(β2MG) in patients with diabetic nephropathy. Methods Immunoturbidimetry was used to measure β2MG in serum and urine from 98 patients with type 2 diabetes and 38 normal patients. Among 98 cases of diabetes, 50 cases were diabetic nephropathy while the other 40 cases were Serumal
and urinary β2MG were significantly elevated in patients with diabetic pared with those in normal patients () No marked difference of serumal β2MG was detected but significant differences of urinary β2MG were found between nonnephropathy diabetes and normal persons (). Conclusion Measuring serumal and urinary β2MG is valuable to the diagnosis of diabetic nephropathy.
Keywords: β2microglobulin; diabetic nephropathy; serum; urine
目前20%~50%的2型糖尿病患者发生糖尿病肾病(diabetic nephropathy,DN),已成终末期肾病发生的主要原因。对糖尿病肾病患者及早进行诊断并且适当干预治疗,可能使肾脏病变发生逆转,这对控制糖尿病患者的病情发展具有重要的意义。血、尿β2微球蛋白(β2MG)作为糖尿病肾病早期敏感指标已被普遍认识,但血、尿β2MG检测在DN中的临床应用价值报道不多[1]。我们检测98例2型糖