文档介绍：阿托伐他汀钙治疗颈动脉粥样硬化疗效观察
(作者:___________单位: ___________邮编: ___________)
【摘要】目的观察阿托伐他汀钙在颈动脉粥样硬化中的治疗效果。方法 92例合并颈动脉粥样硬化以及血脂异常的缺血性脑血管病患者随机分为常规治疗组46例,阿托伐他汀钙治疗组46例(常规治疗基础上加阿托伐他汀钙治疗)分别给予相应的药物治疗12个月;比较2组治疗前后血清C反应蛋白(CRP)、血脂水平以及颈动脉内中膜厚度(IMT)、颈动脉斑块面积的变化以及脑血管事件的复发率。结果 2组治疗前后血清CRP水平较治疗前显著降低();阿托伐他汀钙组治疗后颈动脉IMT、斑块面积以及血脂水平显著降低();常规治疗组治疗前后颈动脉IMT、斑块面积以及血脂水平差异无统计学意义;2组患者脑血管病复发率差异无统计学意义。结论阿托伐他汀钙干预对于降低CRP水平,延缓和逆转劲动脉粥样硬化优于常规治疗组,并可能预防脑血管病复发。
【关键词】颈动脉粥样硬化;阿托伐他汀钙;常规治疗
【Abstract】 Objective To observe the effects of intervention with atorvastatin?calcium?on carotid artery atherosclerosis (CAA).Methods ytwo patients with ischemic cerebrovascular disease plicated CAA and bloodlipid abnormality were randomly divided into atorvastatin calcium group(n=46) and conventional treatment group(n=46).Each group received corresponding therapy for 12 changes of serum Creactive protein(CRP) level,bloodlipid level,treatment and the recurrence rate of cerebrovascular the carotid artery intimal and media thickness (IMT),the plaque areas before and after treatment and the recurrence rate of cerebrovascular event among the 2 groups pared .Results The levels of serum CRP were significantly decreased in the 2 groups after treatment (all ); the carotid artery IMTs,plaque areas and bloodlipid levels in atorvastatin calcium group was significantly decreased too(all ), but there was no sig