文档介绍：藏药川西獐牙菜对小鼠免疫性肝损伤的治疗作用
【摘要】目的探讨藏药川西獐牙菜的醇提物对小鼠免疫性肝损伤的影响,进一步评价其降酶、保肝护肝的作用。方法采用尾静脉注射卡介苗(BCG)和脂多糖(LPS)复制免疫性肝损伤模型,测定血清ALT、AST活性,计算肝脏、脾脏、胸腺质量指数。结果川西獐牙菜的高、中、低剂量给药组连用10d可显著抑制免疫性肝损伤小鼠血清ALT、AST活性,并能有效防止BCG+LPS对小鼠各脏器的免疫性肝损伤。结论川西獐牙菜预防性给药能减轻免疫性肝损伤对小鼠肝脏的破坏,保护肝功能。
【关键词】免疫肝损伤川西獐牙菜脏器指数丙氨酸氨基转移酶(ALT) 天门冬氨酸氨基转移酶(AST) 小鼠
ABSTRACT: Objective To observe the therapeutic effect of Swertia mussotii Franch is extracted by alcohol on immunological liver injury in mice, and further evaluate its immun-regulating effect in decreasing aminotransferase and protecting heptocytes. Methods BCG ine and haride were intravenously injected to establish liver injury model. The effects of Swertia mussotii Franch on liver injury were contrasted. Results The high-, medium- and low- dose Swertia mussotii Franch groups which had been administered for 10 consecutive days, had significantly inhibited serum ALT and AST acticities of immunological liver injury; Swertia mussotii Franch could effectively prev
ent immunological liver injury by BCG+LPS. Conclusion Swertia mussotii Franch can protect mice from immunological liver injury and protect the function of liver.
KEY WORDS: immunity; liver injury; Swertia mussotii Franch; organ index; alanine aminotransferase (ALT); aspartate aminotransferase (AST)
藏药川西獐牙菜(swertia mussotii franch),藏药名桑蒂或蒂达,始载于藏医药书《四部医典》,有清热、解毒,清肝利胆的功效,在历代的藏医药著作如《晶珠木草》、《鲜明注释》等均有记载。川西獐牙菜属龙胆科(gent