文档介绍：藏药涤痰平喘胶囊剂水提工艺研究
作者:黄红英张建华盛春帅李喘胶囊制剂提取工艺。方法以浸膏得率和淫羊藿苷的含量为指标,采用L9(34)正交设计法筛选最佳提取工艺。结果制备工艺影响因素依次为:煎煮时间(A)>煎煮次数(B) >加水量(C),最佳制备工艺条件为A1B3C1,即去油达玛(陇蜀杜鹃)药渣和处方量的皂荚、淫羊藿等加8倍量水,提取3次,每次40 min。结论筛选的制剂工艺合理,质量稳定可靠;淫羊藿苷含量测定为该制剂质量控制提供依据。
【关键词】涤痰平喘胶囊;淫羊藿;高效液相色谱
Abstract:ObjectiveTo screen of aqueous extraction process of Ditanpingchuan capsule in Tibetan medicine method using the yield of extractum and the content of icariin as indexes, the optimum extraction conditions of Ditanpingchuan capsule was studied with the orthogonal test L9 (34).ResultsThe influencing power of factor was described as: A> B>C (A: decoction times, B: decoction frequency, C: added water volume). The optimum preparation conditions were A1B3C1, . drugs of a decoction of Rhododendron przewalskii Maxim without volatility oil and Gleditsia, Icariin, 8 times volume of water, decoction for 3 times and 40 minutes every time. ConclusionThe optimum extraction procedures are rational,fe
asible, and provide foundation for production.
Key words:Ditanpingchuan Capsule; Icariin; HPLC
藏医药学是祖国医药学宝库重要的组成部分,凝聚了藏族人民长期与疾病作斗争的宝贵经验,具有独特的理论体系和浓厚的民族特色[1]。涤痰平喘胶囊为青海省中医院根据藏医药理论结合中医药理论生产的中藏药制剂。由达玛(陇蜀杜鹃)、淫羊藿、才屯(麻黄)等配制而成,具有宣肺、豁痰平喘功能。主治寒痰内结、哮喘时乍感寒即发、咳吐痰涎甚多等症,对治疗高原慢性支气管炎、支气管哮喘有良好疗效。为了保证该制剂质量稳定和临床疗效,本文以浸膏得率和淫羊藿苷的含量为指标,采用L9(34)正交设计法筛选最佳提取工艺。
1 仪器与试药
Agilent1100高效液相色谱仪(美厂);RE-85Z旋转蒸发仪(上海青