文档介绍：藏药莪达夏炮制前后药效学实验研究
【摘要】目的通过对藏药莪达夏炮制前后的抗炎镇痛实验研究,探讨该药炮制方法与药效的关系。方法观察莪达夏的抗炎作用和镇痛作用。结果藏药莪达夏炮制前后对大鼠足趾肿胀、小鼠耳肿胀均有明显的抑制作用;炮制前、后莪达夏对醋酸致痛小鼠的扭体次数影响存在显著差异。结论藏药莪达夏炮制前后抗炎作用未发生明显变化;藏药莪达夏炮制前后镇痛作用发生明显变化。
【关键词】藏药莪达夏炮制抗炎镇痛
Abstract Objective To study the anti-inflammatory and analgesic effects of the crude and processed Oxytropis falcate Bunge. Methods The anti-inflammatory and analgesic effects of the crude and processed Oxytropis falcate Bunge were observed. Results The crude and processed Oxytropis falcate Bunge significantly improved the ear edema in mice and the paw edema in rats. There was significant difference between the times of writhes caused by Acetic acid after treated with crude or processed Oxytropis falcate Bunge. Conclusion The anti-inflammatory effect had not changed significantly but the analgesia effect had changed significantly after treated by crude and processed Oxytropis falcate Bunge.
Key words Oxytropis falcate Bunge Crude and processed herbs Aanti-inflammatory A nalgesic effect
《中载:“莪达夏为草药之王,微苦,寒。清热,解毒,生肌愈疮,可内服外用,外用生肌愈疮,去骨瘤;内服涩脉,止血”。[1]莪达夏为有毒植物,分布较广。《藏药志》记载:“治高烧、喉炎、黄水疮、便血、红白痢、创伤流血等,外敷可消肿止痛、祛腐生新,治刀伤。”[2]本实验采用藏药材加工炮制通则中的奶制法,研究莪达夏炮制前后其抗炎及镇痛作用变化。
1 材料与方法
材料
动物
昆明种小鼠,体重(20±2)g;Wistar大鼠,体重(200±20)g。以上动物均由青海实验动物中心提供。
药品
莪达夏采自青海省共和县青海湖畔,经青海大学医学院魏全嘉教授鉴定为镰形棘豆(Oxytropis falcate Bunge)。莪达夏全草水提液:莪达夏粗粉100 g加8倍量水浸泡30 min后煎煮15 min,过滤,滤液在40℃~5