文档介绍：补肺片抗炎止咳作用的实验研究
作者:黄开珍姚平冼寒梅陈旭林国彪
【摘要】目的观察补肺片的抗炎止咳作用。方法用二甲苯致小鼠耳炎症和腹腔毛细血管通透性法观察补肺片对小鼠急性炎症的作用,用小鼠棉球肉芽肿法观察补肺片对小鼠慢性炎症的作用,用浓氨水致咳及小鼠排泌酚红观察补肺片的止咳化痰作用。结果补肺片高、中、低剂量组对二甲苯所致小鼠耳廓肿胀没有抑制作用(P>);补肺片高、中剂量小鼠腹腔毛细血管通透性的急性炎症有明显的抑制作用。补肺片高、中剂量组对小鼠皮下肉芽肿的慢性抗炎具有明显的抑制作用(P<)。补肺片高、中、低各剂量对小鼠浓氨水致咳嗽次数和致咳潜伏期均有明显作用(P<)。对小鼠气管排泌酚红的化痰实验,补肺片高、中、低各剂量组均有明显祛痰作用(P<)。结论补肺片有抗炎,止咳,化痰,增强机体免疫功能的作用。
【关键词】补肺片抗炎止咳
Abstract:ObjectiveTo observe the anti-inflammatory and antitussive effects of Bufei tablets. MethodsThe methods of making ear swellingby xylene and capillary permeability were used to observe the effect of Bufei tablets on acute inflammation in mice. The method of subcutaneous implantation of granuloma formation by cotten observe the effect of Bufei tablets on chronic inflammation in mice. The method of concentrated ammonia inducing cough and mouse excretion of phenol red was used to observe the effect of Bufei tablets. ResultsBufei tabletsin high, middle, low dose groups of xylene-induced ear edema had no inhibitory effect (P>); Bufei tablets in high,middle dose groups significantly inhibited mice capillary permeability of acute inflammation. Bufei tablets in high-dose group significantly inhibited mice s
ubcutaneous granuloma chronic anti-inflammatory (P<). The frequency of cough and latent period of cough caused by strong ammonia and the excretion of phenol red in the airway of mice with was significantly inhibited by Bufei tablets(P<).ConclusionBufei tablets have the effects of anti-inflammation, reducing sputum and relieving cough and enhancing the petence of the body.
Key words:Bufei tablets; Anti-inflammation; Antitussive
肺气虚证是慢性阻塞性肺疾病(chronic obstructive disease COPD,简称为慢阻肺)常见证候,是一种以气流受限为特征的疾病,其气流受限不完全可逆,是进行性发展,与肺部对有害气体或有害颗粒引起的异常炎症有关[1],是一种破坏性的肺部疾病,临床上以咳嗽、咯痰、胸闷等为主症。根据COPD的病理特征,治疗方法主要是辨证论治,治则可概括为祛邪扶正,活血化淤、化痰降气、急则治标,缓则治本或标本兼治。运用中医药治疗COPD具有较好的疗效,尤其是稳定期患者,中医药治疗具有改善症状,减少发作次数,提高免疫功能,而且有不良反应小的优点。根据中医理论,研制出一种中成药制剂
—“补肺片”。该药采用扶正固本的传统方剂“玉屏风散”为