文档介绍：心房钠尿肽对内毒素休克大鼠动脉血压的作用
作者:贾斌李志超戚好文张莉莉董明清王晓斌温光楠
【关键词】心房钠尿肽
关键词: 心房钠尿肽;内毒素休克;血压;大鼠
摘要:目的探讨心房钠尿肽(ANP)对内毒素休克大鼠动脉血压的作用及可能的机制. 方法大鼠静脉给予脂多糖(LPS,2mg・kg-1 )后立即静脉给予ANP(2μg・kg-1 ),记录动物平均动脉血压(MAP),检测血浆一氧化氮(NO)和血浆内皮素(ET)浓度的变化. 结果给予LPS的大鼠MAP持续下降,至4h时MAP下降到(±)kPa;ANP治疗组大鼠MAP在给药初期的短暂下降后逐步回升,至4h时MAP仍维持在(±)kPa,与LPS组相比有显著差异(P<).与对照组比较,LPS组动物4h时血浆NO和ET浓度均显著升高(P<);与LPS组比较,ANP治疗组的动物在4h时血浆NO水平和ET浓度均显著下降(P<),但仍明显高于对照组(P<). 结论 ANP对LPS引起的动脉血压的持续下降有作用,可能是通过拮抗ET的产生、降低NO的分泌而起作用,也可能是通过其他的途径.
Effect of atrial natriuretic peptide on regulation of arterial blood pressure in rat after endotoxic shock
JIA Bin LI Zhi-Chao QI Hao-Wen ZHANG Li-Li DONG Ming-Qing WANG Xiao-Bin WEN Guang-Nan
1 Department of Pathophysiology,Faculty of Pre-clinical Medicine,
2 Department of Respiratory Dis-ease,Xijing Hospital,Fourth Military Medical University,Xi'an710033,China
Keywords:atrial natriuretic peptide;endotoxic shock;blood pressure;rat
Abstract:AIM To investigate the effect of atrial natriuretic peptide(ANP)on the regulation of arterial blood pressure
and their potential mechanism in endotoxic shock Mean arterial blood pressure(MAP)was recorded and nitric oxide(NO)and endothelin(ET)concen-tration of plasma was measured respectively after lipopolysac-charide(LPS)and LPS incorporate with ANP was injected into the veins of Administration of LPS elicited a p
ersistent decrease in MAP(±)kPa could maintain MAP at higher levels [(±)kPa,at4h,P<]after an transient decline when LPS was and ET concentrations in plasma was evi-dently higher in the ANP therapia group than in the control group respectively(P<).Compared with the LPS group,NO and ET concentrations in plasma in the ANP therapia group all significantly decreased(P<).CONCLUSION ANP plays a role in the regulation of arteri-al blood pressure in endotoxic shock induced by ef-fect of ANP