文档介绍：星形细胞肿瘤组织中核因子κB的表达与肿瘤增殖
作者:陈保东,袁先厚,江普查,陈卫国,文志华
【关键词】星形细胞肿瘤
【Abstract】 AIM: To evaluate the significance of nuclear factor kappa B (NFκB) p65 protein expression and their relationship with tumor proliferation. METHODS: The expression of NFκB p65 protein, cyclin D1 protein and proliferating cell nuclear antigen (PCNA) protein in 64 cases of astrocytic tumors and 10 cases of normal brain tissue were studied immunohistochemically. RESULTS: None of the normal tissues exhibited NFκB p65, cyclin D1 protein. In contrast, 35 of 64 astrocytic tumor specimens were positive for NFκB p65 protein with a % positive rate (P<), and 27 of 64 astrocytic tumor specimens were positive for cyclin D1 protein with a % positive rate (P<), the labeling index of PCNA protein were %-%. Normal brain tissue were negative or of low expression for PCNA protein. The NFκB p65 protein, cyclin D1 and PCNA protein expression were correlated to the differentiation (P<).The expression of NFκB p65 was closely related with the expression of cyclin D1 and PCNA. CONCLUSION: NFκB p65 is a new oncogenic protein related to the astrocytic tumors. NFκB p65 upregulates the expression of cyclin D1 and PCNA, then leads to tumor cell malignant proliferation and tumor occurrence.
【Keywords】 nuclear factor of kappa B(NFκB); cyclin D1; proliferating cell nuclear antigen (PCNA); astrocytic