文档介绍：睫状神经营养因子对大鼠视神经损伤后视觉电生理的影响
作者:崔志利惠延年康军王琳
【关键词】视神经
关键词: 视神经;损伤;睫状神经营养因子;闪光视觉诱发电位;大鼠
摘要:目的观察睫状神经生长因子(ciliary neurotrophic TF)对视神经损伤后视觉电生理变化的作用. 方法采用镊夹视神经法制作大鼠视神经损伤模型,TF50ng,并于损伤当时和损伤后1,2,3和4wk时检测夹伤视神经眼的闪光视觉诱发电位(flare-visional evoked potential,F-VEP). 结果视神经夹伤后损伤眼F-VEP的P1波振幅(wave amplitude,WA)在1wk时下降,后回升;峰潜时(wave latency,WL)TF组中WA在视神经夹伤后1wk和2wk时与对照组相比差异显著(P<),WL仅在视神经夹伤后1wk时与对照组相比具显著差异(P<). 结论 TF在早期加强了神经系统对损伤的反应强度,促进了视神经损伤后神经冲动传导功能的恢复.
Keywords:optic nerve;injury;ciliary neurotrophic factor;flare-visional evoked potential;rat
Abstract:AIM To study the effects of ciliary neurotrophic TF)on changes of flare-visional evoked potential(F-VEP)in the crushed optic nerve The optic nerve injury models were induced by crushing the optic nerve2mm an retrobulbar injection TF(50ng)was F-VEP was observed1,2,3and4weeks after The F-VEP P1wave amplitude(WA)of optic nerve-crushed eyes of Spraque-Dawley(SD)rats was decreased at1week after in-jury,then recovered partially P1wave latency(WL)was delayed after after crush,the P1WA TF group was significantly greater than that of the control groups(P<).At1week after crush,the P1WL TF group was shorter than that of the control groups(P<).CONCLUSION An retrob-ulbar injection TF after optic nerve crush can enhance the res