文档介绍：双诺希胶囊对实验性高脂血症的影响
作者:贺建荣程建峰刘德强
【关键词】双诺希胶囊
关键词: 双诺希胶囊;高脂血症;胆固醇;三酰甘油;大鼠
摘要:目的验证双诺希胶囊(SHNX)对高脂血症大鼠血脂的影响. 方法用高脂饲料喂饲大鼠建立高脂血症模型;随机分为6组,即正常对照组、高脂模型组、SHNX大剂量组(SHNXH ・kg-1 )、SHNX中剂量组(SHNXM ・kg-1 )、SHNX小剂量组(SHNXL ・kg-1 )和安妥明组(Clofibrate),连续喂饲并灌胃给药30d后,观察SHNX对高脂血症大鼠血脂含量的影响. 结果 SHNX能明显降低血清总胆固醇(TC)、三酰甘油(TG)含量,亦能明显提高血清高密度脂蛋白亚组分Ⅱ胆固醇(HDL2 -C)及高密度脂蛋白胆固醇(HDL-C)的含量. 结论 SHNX对血脂紊乱大鼠有明显的治疗效果.
Keywords:Shuangnuoxi capsule;hyperlipidemia;choles-terol;triglyceride;rats
Abstract:AIM To verify the effect of Shuangnuoxi capsule(SHNX)on blood lipid in rats suffering from Five acute hyperlipidemia models of rats were establisthed with high fat feed,followin
g administration of ,,・kg-1 and g・kg-1 the levels of blood lipid in rats suf-fering from hyperlipidemia were observed after being given different dosages of SHNX given orally obviously decreased the levels of serum cholesterol(TC),serum triglyceride(TG)but remarkably increased the levels of high density lipoprotern subgroup2-cholesterol(HDL2 -C)and high density lipoprotein SHNX has a marked therapeutic effect on dislipidemia in rats by modulating blood lipid.
0 引言
双诺希胶囊(Shuangnuoxi capsule,SHNX)是我院药剂科与陕西心脑血管病研究所德通医院科研人员在长期临床实践的基础上研制出的一种治疗高脂血症、[1] 、绞