文档介绍：静脉用丙种球蛋白治疗儿童过敏性紫癜疗效观察
作者:陆彪,梁丽俊,邓璐璐,赵银霞,马立燕
【摘要】目的探讨静脉用丙种球蛋白(IVIG)对小儿过敏性紫癜的治疗效果。方法将58例混合型过敏性紫癜患儿随机分成丙球治疗组28例、激素治疗组30例,另设常规对照组40例,观察皮疹、关节症状、腹痛消失时间及3个月内肾损情况,并对结果进行统计学分析。结果①丙球治疗组在皮疹、腹痛、关节症状消失时间及住院时间均显著短于常规对照组(P<);②丙球治疗组与激素治疗组相比,在皮疹消退及住院天数上差异有统计学意义(P<)。③治疗3个月后,丙球治疗组肾损害的发生率明显低于另外两组(P<)。结论 IVIG对过敏性紫癜疗效满意。
【关键词】过敏性紫癜;静脉用丙种球蛋白;儿童
Abstract:Objective To evaluate the effectiveness of IVIG in treating Henoch-Schonlein purpura of A total of 58 patients with Henoch-Schonlein purpura were randomly divided into 2 first group were administrated IVIG,the second group were administrated Methylprednisolone,while other 4+0 patients who received the routine treatment parison
ction time of rash,joint symptom,abdominal pain and kidney lesion during three-month treatment were observed and ① IVIG group was significantly shorter than conventional therapy group in extinction time of rash,joint symptom,abdominal pain and length of stay(all P<);② Comparing IVIG group with corticoid group respectively,significant difference in extinction time of rash and length of stay were found(both P<);Using gammaglobulin,rash disappeared faster and length of stay reduced significantly.③The incidence of kidney lesion of IVIG group was significantlyshorter than the other two groups after three-month treatment(both P<).Conclusion IVIG