文档介绍：抗环瓜氨酸肽抗体与类风湿关节炎骨侵蚀的相关性
作者:吴殿臣, 张正宇, 谭魁麟, 谭军, 饶艳婷
【摘要】目的: 探讨类风湿关节炎(RA)骨侵蚀与抗环瓜氨酸肽抗体(抗CCP抗体)的相关性。方法: P抗体阳性组与阴性组,于治疗前后分别计算X片中骨侵蚀Sharp评分及疾病活动度DAS28评分,对两组之间差异进行统计分析。结果: 抗CCP抗体阳性组64例, ±,±; 抗CCP抗体阴性组48例,±,±。±,±,±,±,治疗后两组Sharp评分差异有统计学意义,阳性组大于阴性组;而治疗后两组DAS28评分差异无统计学意义。结论: 抗CCP抗体与X线提示的RA骨侵蚀有相关性。
【关键词】类风湿关节炎; 骨侵蚀; 抗环瓜氨酸肽抗体; Sharp评分
Relationship between anticyclic citrullinated peptide antibody
[Abstract] Objective: To explore the relationship between anticyclic citrullinated peptide antibody (P antibody)and erosion of bone in rheumatoid arthritis. Methods: The data of 112 patients with RA were analyzed, including radiographic damage of hands (Sharp grades) and P in serum. Results: All patients were classified into P positive group and P negative group. The initial Sharp′s grades of P positive group including 64 patients were ± and arrived at ± two years later. Comparatively, the initial and 2 years later Sharp′s grades of P negative group including 48 patients were ± and ± respectively. The DAS28′s score of P positive group was ± initially and changed to ± two years later. The DAS28′s score of P negative group declined from ± to ±. Conclusion: T