文档介绍：几种抗炎药对大鼠抗炎及血清细胞分子影响的研究
作者:高惠英,毕树雄,国秀忠,王永丰
【摘要】目的比较研究非甾体抗炎药醋氯芬酸、双氯芬酸和布洛芬对佐剂性关节炎大鼠的抗炎作用,并探讨其作用机制。方法应用弗氏完全佐剂制作AA动物模型,将Wistar大鼠35只随机分为正常对照组、模型组、醋氯芬酸组、双氯芬酸组和布洛芬组5组,通过组织学及双抗体夹心ELISA法检测比较5组大鼠关节局部的炎症情况,及其外周血细胞因子IL1β和IL6的含量。结果在醋氯芬酸组、双氯芬酸组和布洛芬组大鼠关节炎的炎症反应明显轻于模型组。细胞因子IL1β和IL6的含量在醋氯芬酸组、双氯芬酸组和布洛芬组均低于模型组(P<);且醋氯芬酸组低于双氯芬酸组和布洛芬组(P<);而双氯芬酸组和布洛芬组间无显著差异(P>)。结论醋氯芬酸、双氯芬酸和布洛芬均能降低AA大鼠血中的IL1β和IL6含量,有较好的抗炎作用,醋氯芬酸作用相对较为显著。
【关键词】佐剂性关节炎;白细胞介素1β;白细胞介素6;非甾体抗炎药
Abstract:Objective To investigate the antiinflammatory effects and mechanism of action of nonsteroidal antiinflammatory drugs [NSAIDs:aceclofenac,diclofenac,and ibuprofen] in AA AA animal models were established by subcutaneous injection plete
Freund′s adjuvant into the right hindpaw ().35 Wistar rats were randomly divided into the normal control group,model group,aceclofenac group,diclofenac group,and ibuprofen joints inflammation rate,serum concentrations of interleukin1β(IL1β),and interleukin6(IL6) were with the model group,the foot swelling rate and serum concentrations of IL1β and IL6 of aceclofenac group,diclofenac group,and ibuprofen group decreased significantly(P<).The serum concentrations of IL1β and IL6 in aceclofenac group were lower than in both diclofenac group and ibuprofen group(P<),and they were identical in diclofenac group and ibuprofen gro