文档介绍：梗塞心肌摄取锝标抗心肌肌凝蛋白轻链mAb 99Tcm
【关键词】肌凝蛋白轻链
【Abstract】 AIM: To study the influential factors of uptake of ium99m labeled anticardic myosin light chain monoclonal antibody (99TcmAMLCA) in infarcted myocardium in rats. METHODS: The ratio was calculated between infarcted and normal myocardium after injecting certian dose of 99TcmAMLCA in the experimental myocardial infarction in rats and the relationship was observed between the radioactivity uptake in infarcted myocardium and injection time, infarction time and zone region of infracted myocardium. RESULTS: The infarcted myocardium uptook 99TcmAMLCA rapidly at the first 2 h, increased towards steady at 4~8 h and reached the peak at 24 h after injection. Compared with the ratios of 99TcmNIgG in the infarcted with normal myocardium, the ratios of 99TcmAMLCA were significantly higher at the same time after injection (P<). There were a greater uptake of 99TcmAMLCA in the infarcted myocardium during the phase of acute myocardium infarction (AMI).The uptake of 99TcmAMLCA in the infarcted myocardium in the endiocardial layers at the infarct center was greater than other zone regions of infracted myocardium. CONCLUSION: The uptake of 99TcmAMLCA is specific, rapid and long lasting in the infarcted myocardium and is hardly affected by infarct time. This may probably e a new approach to myocardial infarct imaging.
【Keywords】 myosin