文档介绍：【word】多发性乳腺纤维腺瘤患者免疫组化相关指标的研究多发性乳腺纤维腺瘤患者免疫组化相关指标的研究墼堂箜甄螽|,]1117;;2浙江省中医院乳腺病诊疗中心摘要目的:探讨多发性乳腺纤维腺瘤的病因和发病机理,:用免疫组化法检测9O例多发性乳腺纤维腺瘤患者和3O例乳腺增生病患者乳腺组织中雌激素受体(estro—genreceptor,ER),孕激素受体(progesteronereceptor,PR),细胞增殖抗原标记物(),抑癌基因P53及人类癌基因CerbB-:(1)多发性乳腺纤维腺瘤患者PR的阳性表达率及高强度阳性表达率均高于对照组(前者P<,后者P<);Ki一67的阳性表达率明显高于对照组(P<);(2)多发性乳腺纤维腺瘤患者ER,PR之间有显着相关性(P<);(3)多发性乳腺纤维腺瘤患者ER的阳性表达率与对照组相比无显着性差异(P>);(4)多发性乳腺纤维腺瘤患者ER,PR与Ki-67的表达之间无相关性(P>);(5)P53和CerbB-:(1)局部乳腺组织中PR的阳性表达率及阳性表达强度升高也是乳腺纤维腺瘤发病的主要因素;(2)ER,PR间存在的相关性在本病的发生中起了主要作用;(3)Kb67的阳性表达率升高,说明细胞增殖能力较强,::A文章编号:(20l1)10—1117—04‘I1leStudyOntheRelativeImmunohistochemicalIndexinthePatientwithMultipleVibroadenomaofBreastZHANGXiuxia*,LOULihua,ZHANGQirig.*DepartmentofGermralSurgery,theYuhangDistrictFirstPeople’SHospitalofHangzhouCity,ZhejiangProvince311000ABSTRACTObjective:hepathogenesisofmultiplefibroadenomaofbreastanddiscussthesignificanceofimmunohIl,1,.hemicalindicatrixintheprocessofthediseas~Methods:Theexpressionofeslrogenreceptor(ER),pro—gesteronei’tceptor(PR),theeellproliferatingantigenKi一67,anti-oncogeneP53andhumanoneogeneCerbB-2weretest-edbytheimmunohistochemicalassayin90caseswithmultiplefibroadenomaofbreastand30caseswithmammaryhy—:(1)ThepositiverateandthepowerfulpositiverateofPRexpressionwerebothhigherthanthatinhealthycontrolgroupsignificantly(respectivelyP<,P<).(2)TherewassignificantdependabilitybetweenERandPRintheeaseswithmultiplefibroadenomaofbreast(P<).(3)TherewasnosignificantdependabilityforthepositiverateofERexpressionbetweenthecaseswithmultiplefibroadenomaofbreastandthecontrolgroup(P~).(4)Therewasnosignificantdependab],itybetweentheexpressionofERandPRandtheexpressionofKi一67(P>).(5)TherewasnoexpressionofP53andCerbB-2intheeaseswithmultipl