文档介绍：表柔比星术后膀胱灌注防治非肌层浸润性膀胱癌术后复发的疗效观察
作者:李锋,曾顺生作者单位:广东省梅县人民医院泌尿外科,广东梅州
【摘要】目的:观察表柔比星膀胱灌注防治初发非肌层浸润性膀胱癌术后复发的临床效果和毒副反应。方法:将62例非肌层浸润性膀胱癌手术患者随机分为观察组和对照组,每组各31例。两组均采用TURBt手术治疗,术后观察组采用表柔比星膀胱灌注治疗,对照组采用卡介苗(BCG)膀胱灌注治疗,随访1年评价两组复发率,观察毒副反应。结果:%,%,两组复发率比较差异有统计学意义(P〈);%%,但两组比较差异无统计学意义(P〉);Ⅱ~Ⅲ%,%,两组比较差异有统计学意义(P〈)。结论:表柔比星膀胱灌注可以有效地预防非肌层浸润性膀胱癌的术后复发,且毒副作用小,表柔比星是一种疗效确切、安全可靠的膀胱灌注药物。
【关键词】非肌层浸润性膀胱癌,表柔比星,膀胱灌注,复发
[ABSTRACT] Objective: To observe the effect and safety of intravesical perfusion of epirubicin (EPI) on postoperative recurrence of normuscle invasive bladder cancer. Methods: A total of 62 cases with bladder cancer surgery were randomly divided into observation group and control group. All patients were treated by TURBt surgery. Patients in observation group were treated by EPI intravesical perfusion, while patients in control group were treated by intravesical perfusion of bacillus calmette-guerin(BCG). A 1-year follow-up was conducted to evaluate the recurrence rates and the toxicity. Results: The recurrence rate of observation group in the follow-up period was %, while the control group was %, with significant difference (P〈). The incidence rate of toxicity of the observation group was %, while the control group was %, without significant difference (P〉). The incidence rate of
Ⅱ~Ⅲ