文档介绍：
骨桥蛋白及其受体 CD44v 对肿瘤侵袭调控
的研究进展#
孙冰生,裴宝祥,王安雷,张真发**
5
(天津医科大学附属肿瘤医院肺部肿瘤科天津市肿瘤防治重点试验室天津市肺癌诊治中
心
300060)
摘要:骨桥蛋白(osteopontion,OPN)是胞外基质中具有多种功能的分泌型糖蛋白,既可作为
一种粘附蛋白,参与肿瘤细胞粘附、迁移;又可作为一种细胞因子,促进肿瘤血管形成、
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逃避免疫监视及抑制细胞凋亡。CD44v 糖蛋白是细胞表面黏附分子之一,介导细胞-基质和
细胞-细胞间相互作用。近年来大量研究表明 OPN 及其受体 CD44v 促进肿瘤侵袭转移,其
血清水平与多种肿瘤的预后相关。因此,阐明 OPN 在肿瘤演进的分子机制及其信号通路有
助于寻找一种新颖抗癌疗法。
关键词:骨桥蛋白;CD44v;信号通路;肿瘤演进
中图分类号:
The research progress of osteopontin and CD44v in the
tumor invasion and metastasis
SUN Bingsheng, PEI Baoxiang, WANG Anlei, ZHANG Zhenfa
(Tianjin Cancer Institute and Hospital, Tianjin Medical University, Key Laboratory of Cancer
Prevention and Therapy of Tianjin, Diagnosis and Therapy of Lung Cancer of Tianjin, Department
of Lung Cancer Surgery, Tianjin Lung Cancer Center, Tianjin 300060, China)
Abstract: Osteopontin (OPN) is a multifunctional, extracellular matrix- associated, secretory,
glyco-protein. It can be used as an adhesion protein involved in tumor cell adhesion,migration; but
also as a cytokine, promoting tumor angiogenesis, evading immune surveillance and inhibiting
cellular apoptosis. CD44v glycoprotein, is one of the cell surface adhesion molecule that mediates
cell-matrix and cell-cell interactions. Extensive research has suggested the important role of OPN
in regulating signaling pathways that contribute to tumor progression and meta