文档介绍：
Influence of Liquid Lipid Content on the Properties of
Puerarin-loaded Lipid Nanoparticles#
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HU Xiaofen*
(College of Bioengineering, Zhejiang Chinese Medical University, Hangzhou 310053)
Abstract: The present study described the fabrication and characterization of puerarin-loaded lipid
nanoparticles with blends of glyceryl monostearate (solid lipid phase) and DELIOS® MCT (liquid
lipid phase) as the lipid matrices. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers
(NLC) were prepared via controlling the ratio of liquid lipid to solid lipid. The drug-patibility
was evaluated via theoretical calculation of solubility parameters and X-ray diffraction analysis. The
influence of liquid lipid content on the particle size, morphology, stability, drug loading properties of
the lipid nanoparticles and in vitro release behavior of puerarin was investigated. Both SLN and NLC
exhibited well stability and spherical shapes, and no significant difference in particle size occurred for
the NLC series. The drug loading capacity (LC) and entrapment efficiency (EE) of the lipid
nanoparticles were affected as increasing the liquid lipid content, and the presence of liquid lipid had a
positive effect on improved drug payload. The in vitro release behavior of puerarin was intimately
associated with the constituent of the lipid matrix