文档介绍：华东交通大学基础科学学院
课程名称:有机合成
专业: 应用化学

教师: 何忠义博士
Organic chemistry:
of natural products
2. anic chemistry
3. Organic synthesis
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Textbooks
Principles anic Synthesis by
and
新编有机合成化学, 黄宪,王彦广等编
现代有机合成化学, 吴毓林,姚祝军编著
有机合成化学与路线设计,巨勇,赵国辉等编著
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Introduction: the History and Perspective anic Synthesis
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Organic Synthesis in Its Nascent Times
Woehler, synthesis of urea from ammonium cyanate in 1828, a breakthrough from the theory of “vital force”
Kolbe, synthesis of acetic acid from elemental carbon in 1845, and creation of the word “synthesis”
Syntheses of alizarin(1869), indigo(1878) spurred the legendary German dye industry and represent the landmark plishment in the field.
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Some Natural Products Synthesized Before World War II
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The Contributions of Woodward and Corey to the Development anic Synthesis
R. B. Woodward(1917-1979), Nobel laureate in 1965
Total synthesis of VB12(1973), cortisone(1951), strychnine (1954), lysergic acid(1954), reserpine(1958), chlorophyll(1960)
colchicine(1965), PGF2α(1973), erythromycin A(1981), etc.
Establishing an epoch of massive synthesis of natural products, and hence turning the synthesis into a fine art.
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Vitamin B12
E. J. Corey(1928-), Nobel laureate in 1990
Hundreds plicated natural and pounds
Theory of retrosynthetic analysis
New synthetic methods
Asymmetric synthesis
Mechanistic proposal
Important contributions to biology and medicine
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Palytoxin