lncRNA与miRNA相互调控作用及其与肿瘤的关系研究.doc

文档介绍：
lncRNA 与 miRNA 相互调控作用及其与肿
瘤的关系研究
武明花1,2,李桂源1,涂超峰1,2*
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(1. 中南大学肿瘤研究所,卫生部癌变原理重点实验室,教育部癌变与侵袭原理重点实验
室,长沙 410078;
2. 湖南省颅底外科与神经肿瘤临床医疗技术研究中心,长沙 410078)
摘要:lncRNA(long non-coding RNA,lncRNA)是一类转录本长度大于 200bp 的非编码 RNA,
可作为人类基因组中一类重要的调控分子通过多种方式发挥其生物学功能。近年来的研究表
明,lncRNA 也可以作为一种竞争性内源性 RNA (competing endogenous RNA, ceRNA) 与
miRNA 相互作用,参与靶基因的表达调控,并在肿瘤的发生发展中发挥重要的作用。本综
述在简要介绍 lncRNA 功能研究现状和主要研究方法的基础上,进一步分析了 lncRNA 与
miRNA 之间的互相调控关系及其在肿瘤发生发展中的作用,以便为后续的研究提供新的思
路。
关键词:lncRNA;microRNA;研究方法;肿瘤
中图分类号:Q-1; Q-3; R74; Q75
The Interaction Between LncRNA And MicroRNA in tumor
WU Minghua1,2, LI Guiyuan1, TU Chaofeng1,2
(1. Cancer Research Institute, Central South University, Key Laboratory of Carcinogenesis and
Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of
Health Center, ChangSha 410078;
2. The Center for Skull Base Surgery and Neuro-oncology of Hunan Province, ChangSha 410078)
Abstract: Long non-coding RNA(LncRNA) is a kind of non-protein coding RNA, and its
transcription are more than 200 bases in length. LncRNA plays important biological roles as an
regulatory molecule by a variety of mechanisms. Recent studies show that LncRNA can interact
with the miRNA as peting endogenous RNA(ceRNA) to participate in the expression
regulation of target genes, which exert an important role in the initiation an