文档介绍：
姜黄素纳米复合物的制备与表征#
谢洁红,夏书芹,张晓鸣**
(江南大学食品学院,食品科学与技术国家重点实验室,江苏无锡 214122)
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摘要:以壳聚糖和阿拉伯胶为壁材,利用两者之间的聚电解质络合反应制备姜黄素纳米复合
物,用以提高姜黄素的水溶性和稳定性。以粒径分布、包封率、保留率为指标优化了复合物
的配方和制备工艺。结果表明:在多糖浓度均为 %(w/v),pH 为 ,两种多糖质量比
为 1:1,姜黄素添加量为多糖的 4%,吐温 80 与磷脂比例为 1:1,小分子乳化剂添加量为姜
黄素的 10 倍时,制得的复合物平均粒径为 270nm,多分散指数为 ,包封率为 %,
经过两周贮藏后,粒径分布保持相对稳定,姜黄素保留率可达 %。通过红外分析证实
了复合物的形成,X-射线衍射结果表明姜黄素由晶型状态向无定形状态转变。
关键词:壳聚糖;阿拉伯胶;姜黄素;稳定性;存在状态
中图分类号:
Preparation and characterization of curcumin plex
XIE Jiehong, XIA Shuqin, ZHANG Xiaoming
(State Key Laboratory of Food Science and Technology, School of Food Science and Technology,
Jiangnan University, JiangSu WuXi 214122)
Abstract: Curcumin plex was prepared by the lexation of chitosan
and Arabic gum to enhance the solubility and stability of this pigment. Based on the size
distribution, encapsulation efficiency and retention rate, the optimal conditions were determined as
follows: concentration of haride %(w/v), pH , mass ratio of chitosan and Arabic
gum 1:1, additive amount of curcumin was 4% of harade, mass ratio of Tween 80 and
phospholipid 1:1, total amount of small molecular emulsifier was 10 times of curcumin. Under
this condition, the average size plex reached to 270nm, polydispersity index , the
encapsulation efficiency of curcumin was %. The size distribution remained stable and the
retention rate was % after storage of two weeks. The FTIR analysis confirmed the formation
plex. The X-ray diffraction results demonstrated that the exsisting state of curcumin
transformed from crystal form to amorphous state.
Keywords: chitosan; Arabic gum; curcumin; stability; existing state
0 引言
姜黄素是从中药姜黄中提取的一种植物多酚,是植物界中少有的含有二酮结构的色素。
近 30 年研究表明,姜黄素具有抗炎、抗氧化、降血脂、抗动脉粥样硬化、抗肿瘤等多种功
能性质[1]。然而姜黄素水溶性差,大部分进入人体后从粪便排出,在血液中浓度低,生物利
用率低限制了它的应用[2]。
将功能性成分纳米化是改善其水溶性、提高分散率及生物利用率的一种有效途径[3]。相
比于微米级材料而言,纳米级材料体积小、流动性好,穿透作用更强,细胞摄取率也更高[4]。
近年来,应用于姜黄素的纳米载体形式有多种:纳米粒[5] [6]、磁性纳米粒[7]、纳米乳[8]、
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纳米