钴铜双金属纳米颗粒的合成及其抗菌性能研究.doc

文档介绍：
钴铜双金属纳米颗粒的合成及其抗菌性能
研究#
谢谋哲,高锦豪**
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(厦门大学化学化工学院化学生物学系,福建厦门 361005)
摘要:随着纳米科技的发展,纳米材料的抗菌性能也受到了越来越多的关注。抗菌效果良好
的纳米颗粒在包装材料、抗菌器件、生物医药等多个领域都拥有巨大的发展潜力。本工作设
计了 CoCu 双金属纳米颗粒,并采用高温热分解法制备得到粒径均一,分散性良好的 CoCu
纳米颗粒;通过 2,3-二巯基丁二酸(DMSA)对合成出的纳米颗粒进行表面修饰,改善了纳
米颗粒在水中的分散性,并且表面带负电荷。采用表达红色荧光蛋白的大肠杆菌菌株对 CoCu
纳米颗粒进行抗菌性能研究,结果表明其具有良好的抑菌效果;采用 SMMC-7721 人源肝癌
细胞模型对 CoCu 纳米颗粒进行细胞毒性研究,结果表明其对癌细胞具有细胞毒性。本文显
示了 CoCu 纳米颗粒在抗菌等生物医学领域具有广阔应用前景。
关键词:CoCu 双金属纳米颗粒;高温热分解;抗菌性;细胞毒性
中图分类号:O648
Synthesis of CoCu bimetallic nanoparticles and their
antibacterial property
XIE Mouzhe, GAO Jinhao
(Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen
University, FuJian XiaMen 361005)
Abstract: As the booming development of nanoscience and nanotechnology, researchers draw
more and more attentions on the antibacterial property of nanomaterials. Generally speaking,
nanoparticles (NPs) with obvious antibacterial property have a great potential in the fields of
packaging materials, new antibiotics, and sterile coatings for biomedical devices. Herein, we
report the synthesis of novel cobalt-copper (CoCu) bimetallic NPs through thermo position
process. The CoCu NPs have a narrow size distribution and good monodispersity. We used
meso-2, 3-inic acid (DMSA) small molecule to transfer the NPs in water through
double-exchange surface modification and obta