文档介绍：
毒死蜱和乐果联合染毒对大鼠肝脏抗氧化
酶活性的影响#
乙楠楠,吴惠,李亭亭,何贤松,姚欣雅,赵敏娴,王灿楠**
5
10
15
20
25
30
35
40
45
(东南大学公共卫生学院环境医学工程教育部重点实验室/营养与食品卫生系,
南京 210009)
摘要:目的研究毒死蜱和乐果联合染毒对大鼠肝脏超氧化物歧化酶(SOD)、过氧化氢酶
(CAT)活性及过氧化物丙二醛(MDA)浓度的影响。方法选用毒死蜱和乐果的 NOAEL
和 1/50LD50 两个剂量水平,采用 2×2 析因设计,按体重随机分为 1 个阴性对照组和 4 个剂
量组,每组 10 只大鼠。 5 个组分别为阴性对照组 0mg/(kg·bw)/d;毒死蜱+乐果组:
+/(kg·bw)/d,+/(kg·bw)/d,+/(kg·bw)/d,+ mg/(kg·bw)/d。
结果析因分析显示,毒死蜱和乐果联合染毒,可提高大鼠肝脏 SOD、CAT 活性及 MDA 浓
度,且随剂量增加而增大,联合作用模式均为相加作用。结论毒死蜱和乐果联合染毒可增
加大鼠肝脏 SOD、CAT 两种抗氧化酶的活性及过氧化物 MDA 的浓度,联合作用特征为相
加作用。
关键词:营养与食品卫生;有机磷农药;联合作用;超氧化物歧化酶;过氧化氢酶;丙二醛
中图分类号:R114
Joint Toxic Action of Chorpyriphos and Dimethoate on the
Antioxidant Enzymes of Rats Liver
YI Nannan, WU Hui, LI Tingting, HE Xiansong, YAO Xinya, ZHAO Minxian,
WANG Cannan
(The key laboratory of medical engineering environment/Nutrition and Food Hygiene Department,
School of Public Health, Southeast University, Nanjing 210009)
Abstract: Objective To study bined toxic effect of chorpyriphos and dimethoate on the
antioxidant enzymes and lipid peroxidation products of the female rats, including superoxide
dismutase, catalase and malondialdehyde. To acquire a further understanding of the mechanism of
anophosphorus pesticides affect the human body. Methods Chorpyriphos and dimethoate
used in the experiment were both at the dose of NOAEL and 1/50LD50. The adult fema