文档介绍：
Effects of dibutyl phthalate on ovarian active substance of
mice#
WANG Yu, WANG Shengqing, YE Wengbin, HE Jiujun*
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(Department of Biology and Chemistry, Longnan Teachers College, GanSu ChengXian 742500)
Abstract: With superoxide dismutase(SOD), catalase(CAT), alkaline phosphatase(AKP), acid
phosphatase(ACP), malondialdehyde(MDA) and Bax protein expression as characteristic indexes, the
effects of dibutyl phthalate(DBP) on ovarian active substance of mice were studied, and the toxic
mechanisms were discussed. One hundred sixty mice were given intragastric administration of DBP (0,
100, 250, or 500 mg/(kg·d)), respectively, for 30 days. At 5, 10, 20, 30 days after DBP exposure, the
ovarian examinations were taken. The results revealed that administration of DBP decreased the
activities of SOD, CAT, AKP and ACP, while MDA content and Bax protein expression increased.
Two-way analysis of variance indicated that dose contributed more to DBP-induced ovarian damage
than treatment time. The present study demonstrated that DBP promoted apoptosis and inhibited
antioxidant capacity of the ovarian.
Keywords: Dibutyl phthalate(DBP); Ovarian; Antioxidant capacity; Bax protein; Mice
0 Introduction
It has caused serious concern about dibutyl phthalate, being added to certain foods and
benerages manufactured in Taiwan. DBP is used extensively i