载紫杉醇共聚物胶束的合成与表征.doc

文档介绍：
载紫杉醇共聚物胶束的合成与表征#
李扬龚,钱嫦云,陆菲,徐晓芬,郭圣荣**
(上海交通大学药学院,上海 200240)
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摘要:目的:制备好的紫杉醇载体材料。方法:开环聚合法一步合成了两种两亲性共聚物 PTL1
和 PTL2,以核磁和凝胶渗透色谱进行了产物的表征,以固体分散-超声法制备紫杉醇胶束,考
察了胶束的载药量、包封率。结果:核磁和凝胶渗透色谱的结果显示得到了目标产物,所制
备得到的载紫杉醇胶束包封率可以达到 90%以上,载药量为 %以上。结论:实验结果表明
我们所合成的 PTL1 和 PTL2 是好的紫杉醇载体材料。
关键词:药剂学;开环聚合;载药量;固体分散-超声法;包封率
中图分类号:R918
Preparation and characterization of paclitaxel-loaded
polymeric micelles
LI Yanggong, QIAN Changyun, LU Fei, XU Xiaofen, GUO Shengrong
(School of Pharmacy, Shanghai Jiao Tong University, ShangHai 200240)
Abstract: IObjective: To obtain a good micellar carrier of paclitaxel. Methods: Amphiphilic block
copolymers PTL1 and PTL2, were synthesized by ring-opening polymerization and their
compositon were characterized by 1H-NMR and GPC. Water solubility were investigated.
Paclitaxel micelles were prepared through solid-dispersion-sonication method. The drug loading
and encapsulation efficiency of the micelles were investigated. Results: PTL1 and PTL2 were
essfully synthesized,they had different molecular weights and solubility in water. The drug
loading contents of micelles were higher than % and the encapsulation efficiency were high
than 90%. Conclusion: PTL1 and PTL2 could be promising paclitaxel micellar carriers.
Keywords: pharmaceutics; Ring-opening polymerization; Drug loading; Solid dispersion-
sonication; Encaps