文档介绍：
巨噬细胞迁移抑制因子的功能及其相关信
号通路研究进展#
赵然,姚伟娟**
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(北京大学医学部基础医学院生理与病理生理学系,北京 100191)
摘要:巨噬细胞迁移抑制因子(MIF)是一类具有独特结构的多效免疫调节细胞因子,具有
类似趋化因子的功能。自 1966 年被发现以来,MIF 在人体内的功能,尤其是在非特异性免
疫、免疫细胞招募和炎症反应等方面有了突飞猛进的发展。虽然名字被称为巨噬细胞抑制
因子,但其实 MIF 还具有促炎症反应,促进细胞定向迁移,拮抗糖皮质激素,抑制细胞凋
亡,促进其他促炎因子释放等功能。本文就 MIF 的分子通路和功能方面的研究进展进行综
述。
关键词:巨噬细胞迁移抑制因子;分子通路;功能
中图分类号:Q291
The Functions and Signaling Pathways of Macrophage
Migration Inhibitory Factor
Zhao Ran, Yao Weijuan
(Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking
University Health Science Center, Beijing 100191)
Abstract: Macrophage migration inhibitory factor (MIF) is a pleiotropic immunoregulator which
has a unique structure and a chemokine-like function. Since it was dicovered in 1966, the
functions of MIF have been indicated, such as non specific immunity, the inflammatory cell
recruitment, and reaction to inflammatory. Despite its eponymic activity, MIF also has a
proinflammatory function and promotes the directed migration and recruitment of leukocytes into
infectious and inflammatory sites; it also has functions such as anti-glucocorticoids, anti-apoptosis,
and promoting the release of other cytokines. In this review, we will discuss the molecular
pathways and functions mediated by MIF.
Keywords: Macrophage migration inhibitory factor; Singaling pathway; Function
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