文档介绍：
Establishing a Standard Animal Model of Traumatic Optic
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Neuropathy with FPI#
Yu Jinguo1, Yu Rongguo2, Shen Zhansheng1, Wang Xing1, Zhang Wei2, Lu Yingjuan3,
Yan Hua1**
(1. Department of Ophthalmology, Tianjin Medical University General Hospital , TianJin 300052;
2. Department of Ophthalmology, Tianjin Huanhu Hospital, TianJin 300060;
3. Tianjin Medical University Eye Hospital, TianJin 300384)
Abstract: Objective: To establish an animal model of traumatic optic neuropathy (TON) using fluid
percussion injury (FPI) that resembles the clinical state with or without lens injury, and observe the
different progress of repair using flash visual evoked potential (F-VEP). Methods: Chinese white
rabbits were used as the animal research subjects. Sixty-four healthy Chinese white rabbits (128 eyes)
were divided into two groups according to right and left eyes. The right eyes were selected as the
experimental group (optic nerve injury and lens injury) and the left eyes were used as the control group
(optic nerve injury). The traumatic optic neuropathy was made in both eyes using FPI, meanwhile
rating lens injury was performed by acupuncture needle. According to different observing times,
every group was divided into 8 sub-groups. The function of optic nerve was evaluated using F-VEP,
and the results pared between groups and observing times. Results: At one day post injury,
the latencies of P100 in both groups were longer, and the amplitudes of P100 in both group were lower
than before injury (P<). The duration of longer latency in experimental group was shorter than in
the control group (P<). The latency in experimental group restored more quickly than the control
group. Conclusions:This animal model is made with high ess rate. Macrophage accumulates in
retina and optic tissue because of lens injury. There is a good correlation between F-VEP and
pathophysiology.
Keywords: traumatic optic neuropathy; lens injury; animal