文档介绍：利伐沙班杂质列表-提供lc及hplc广州凯名欧生物科技有限公司**********利伐沙班杂质列表利伐沙班主要是治疗成人静脉血栓的药品中文名称:利伐沙班中文别名:5-氯-N-(((5S)-2-氧代-3-(4-(3-氧代吗啉-4-基)苯基)-1,3-恶唑啉-5-基)甲基)噻吩-2-甲酰胺;利伐沙班中间体英文名称:Rivaroxaban英文别名:5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide;Rivaroxabanintermediates;5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamideCAS:366789-02-8分子式:C19H18ClN3O5S分子量::,具有生物利用度的Xa因子抑制剂,其选择性地阻断Xa因子的活性位点,且不需要辅因子(例如抗凝血酶?)以发挥活性。通过内源性及外源性途径活化X因子为Xa因子(FXa),在凝血级联反应中发挥重要作用。利伐沙班在人体剂量依赖性抑制Xa因子活性,应用Neoplastin?试剂测定的凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)及HepTest?肝素定量检测可见剂量依赖性延长。抗Xa因子活性同样受利伐沙班影响。RivaroxabanDimer1632463-24-pound(Ethyl4-(3-1327778-39-1Oxomorpholino)-Phenylcarbamate)pound(R-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-yl)phenyl-Morpholin-3-OneHCl)RivaroxabanImpurityG721401-53-2RivaroxabanImpurityF550-44-7(N-MethylPhthalimide)RivaroxabanImpurity1RivaroxabanImpurity2RivaroxabanImpurity3RivaroxabanImpurity41429334-00-8RivaroxabanImpurity51365267-35-1RivaroxabanImpurity61415566-28-7RivaroxabanImpurity7RivaroxabanImpurity81365267-36-2RivaroxabanImpurity9446292-08-6RivaroxabanImpurity10RivaroxabanImpurity11446292-10-0广州凯名欧生物科技有限公司**********RivaroxabanImpurity12RivaroxabanImpurity13RivaroxabanImpurity14931204-39-6RivaroxabanImpurity15RivaroxabanImpurity16RivaroxabanImpurity17RivaroxabanImpuri