文档介绍：Drugs for Digestive Sys.
SongHui
>
2017/11/17
OUTLINE
Peptic Ulcer
Digestion
Vomiting
Diarrhea
Cholecystitis
Review-Questions
退出
主菜单
>
<
2017/11/17
Ulcer-Background
Epidemiology
Etiology
Physiology Hcl:P-cell,H2,M1,G-R,H+-pump
DU > GU(3:1)
Young Elder(10Yrs)
General consideration
No Acid No Ulcer
Main Destroy Factors
HCl HP
Protective Barrier
Mucus-HCO3-
登记
退出
主菜单
>
<
2017/11/17
Antiulcer-Classification
Targets HCl
Mucus
HP
2017/11/17
Antiulcer-Classification
A. Alkalizer--- Neutralize HCl
B. Antagonize Rs. on Parietal Cell---
M1,H2,G HCl secretion
C. Inhibitor of H+-Pump
D. Protectors of Mucosa
E. Agents kill HP
2017/11/17
A. Antacids
Mechanism
Alkalizers:To Neutralize HCl
Agents:
Mg(OH)2 Al(OH)3 CaCO3 NaHCO3
ADR
Diarrhea , CO2
2017/11/17
B. H2-R Antagonists
Mechanism
(—) H2-R on Parietal cell
Pharmacologic Effects
HCl
Agents ADR
Cimetidine E2 ,— P450,WBC
Ranitidine
Famotidine
2017/11/17
B. Antagonists of M-R
Mechanism
(—) M1-R on Parietal Cell
Pharmacologic Effects
HCl
Agents ADR
Atropine
Pirenzepine - M1-R selection
2017/11/17
B. Antagonist of G-R
Pharmacologic Effects
Antagonize G-R on Parietal Cell
HCl
Agent
petitively antagonize G-R
2017/11/17
C. H+-pump Inhibitors
Mechanism
-S—SH-H+-K+-ATP H+ K+
Agent: Losec
Pharmacologic effects:
HCl & HP
ics:
ba.: 70% tmax1-3h t1/-1h . .
80% Urine
2017/11/17