文档介绍：依托泊昔联合顺钳时辰化疗治疗小细胞肺癌的临床研究苏州1罗文娟1陈宓2((川北医学院附属第二医院)肿瘤科四川绵阳621000)()【摘要】目的:探讨依托泊昔联合顺钳时辰化疗小细胞肺癌(SCLC)的疗效及安全性。方法:将60例确诊为晚期SCLC的初治患者按四个不同时辰随机分为四组,采用EP方案化疗至少2周期,治疗结束后评效,并观察毒副反应结果:22HALO组RR和中位PFS均高于其他组差异有统计学意义,22HALO的呕吐及白细胞减少?血小板减少发牛率,低于其他时辰组,差异有统计学意义。结论:22HALOEP方案时辰化疗晚期SCLC具有疗效高毒副作用低等优点,可作为晚期SCLC的推荐化疗方案之一。【关键词】小细胞肺癌;时辰化疗;疗效;毒性【【文献标识码]B 【文章编号11003-5028(2015)8-0532-02EfficacyofEPRegimenofChrono-ChemotherapyintheTreatmentofPatientswithAdvaneedSmallCellLungCancerSuZhou1LuoWenJuan1ChenMi2(,TheSecondAffiliatedHospitalofNorthSichuanMedicalCollege,621000)(„Sichuan621000)[Abstract]Objective:ToevaluatetheefficacyandsafetyofEPregimenofchrono-chemotherapyinthetreatmentofthepatientswithadvaneedsmallcellIungcancer(SCLC).Methods:Sixtyinitially-:Theresponserate(RR)andthemedianprogress!onfreesurvival(PFS),thrombopeniaandvomitingin22HALOgroupwerelowerthantheothersgroup,:InthetreatmentofpatientswithadvaneedSCLC,22HALOtherapyischaracterizedbyhighefficiencyandlowtoxicsideeffects‘mendedtherapyforadvanee