文档介绍：浙江大学学报(医学版)JOURNALOFZHEJIANGUNIVERSITY(MEDICALSCIENCES)-214,217文章来源:.cn/med/2000/0005/】治疗慢性动脉闭塞症的临床评估李鸣沈來根张鸿坤潘松龄摘要:H的:。方法:H],用前列腺>E.(PGE.)粉针剂100ug静脉滴注治疗20例作对照。结果:LipoPGE】组与PGE]%%(P>)%%(P<)。结论:LipoPGEi治疗慢性动脉闭塞症用PGEi粉针剂1/10的剂量即能达到同样的疗效,且不良反应显著下降,用药方法简便易行。关键词:前列地尔/治疗应用;动脉闭塞性疾病/药物疗法;微球体屮图分类号:R969,R543 文献标识码:A文章编号:1008-9292(2000)05-0213-02LipoProstaglandinEiinTreatmentofChronicArterialObstructionLIMing,SHENLai-gen,ZHANGHong-kun,etal.(TheFirstAff订istedHospital,CollegeofMedicalSciences,ZhejiangUniversity,Hangzhou310003,China)eAbstract:Objective:T()evaluatetheeffectandsideeffectofLipoPOE,:10ugLipoPGEiwasadministatedintravenouslyto29patientswithchronicarterialobstruction,:%%inLipePGE,andPGE】group(P>).%%inLipoPGEiandPGE,grouprespectively(P<).Conclusion:PGEiand10%LipoPGEicanreachthesameeffecttochronicarterialobstructionandsideeffectdecreasessignifiedntly,:Alprostad订/theruse;lusivediseases/drugther;Microspheres前列腺素EMPGEJ、具有强烈的扩张血管和抑制血小板凝集作用。是H前治疗慢性动脉闭塞症的有效约物之一。但PGEi通过肺循环时,大部分被灭活,传统的粉针剂只能采用大剂量持续静脉给药,由于强烈的血管刺激及其他副作用,限制了PGEi的广