文档介绍：RegulationofGeneExpressioninEukaryotesBIT220Chapter24Opportunitiesforthecontrolofgeneexpressioninthe ellGeneExpressionSpatial–noteverygeneproductneededineverycelltypeTemporal–DifferentgenesexpressedatdifferenttimesEnvironmentalstimuliHormonesEspeciallyseenindevelopment-ansSpatialandTemporalexamplesSpatialTubulininplantsMicrotubulesfoundinmanyplacesTUA1-pollengrains;TUB1-,globingenesTetramer(thenaddhemegroup)Someinembryo,fetusandafterbirthPseudogenes–duplicatedgenew/terminationsignalRegulationChap12–RNAprocessing5’capPolyAtailIntronremovalIneukaryotes,–ontrolmRNAstability:-manyroundsproteinsynthesisfromonemRNAShort–rapidlydegraded,needsmoretranscriptiontoreplenish(half-life)RapidmRNAdegradationmaybedesirableHalf-lifeproblemwithmakingadrug,toomRNAstabilityPolyAtails–.,histonemRNAsnopolyAtails;messageveryshortlivedInductionoftranscriptionNotfoundasoftenineukaryotesasinprokaryotesInductioncanworkby:TemperatureLighthormones