文档介绍：British Journal of Anaesthesia 96 (1): 21–30 (2006)
doi: Advance Access publication November 25, 2005
CARDIOVASCULAR
Effect of fluid loading with saline or colloids on pulmonary
permeability, oedema and lung injury score after cardiac and
major vascular surgery
J. Verheij1y, A. van Lingen2, P. G. H. M. Raijmakers2, E. R. Rijnsburger3, D. P. Veerman3,
W. Wisselink4, A. R. J. Girbes1 and A. B. J. Groeneveld1*
1Department of Intensive Care, 2Department of Nuclear Medicine, 3Department of Anaesthesiology and
4Department of Vascular Surgery, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre,
Amsterdam, herlands
*Corresponding author. E-mail: johan.******@
Background. The optimal type of fluid for treating hypovolaemia without evoking pulmonary
oedema is still unclear, particularly in the presence of pulmonary vascular injury, as may occur
after cardiac and major vascular surgery.
Methods. In a single-centre, prospective, single-blinded clinical trial 67 mechanically ventilated
patients were randomly assigned to receive saline, gelatin 4%, HES 6% or albumin 5%, according to
a 90 min fluid loading protocol with target central venous pressure of 13 and pulmonary capillary
wedge pressure of 15 mm Hg, within 3 h after cardiac or major vascular surgery. Before and after
the protocol, we recorded haemodyn