文档介绍：. II THE EXTRACELULAR MATRIX, CELL-BIOMATERIAL INTERACTIONS
PPT adapted from
Chung-Heng Chiang’s Presentation
1
TISSUE RESPONSE TO INJURY
CELL/TISSUE-BIOMATERIALS INTERACTIONS
TECHNIQUES FOR ANALYSIS OF CELLS AND TISSUES
Inflammation and Repair
Cell Regenerative Capacity
Extracellular Matrix Remodeling
Light Microscopy
Electron Microscopy
Three-Dlmenslonal Interpretation
Artifacts
Artifacts Identification, Genotyping, and Functional Assessment of Cells, Including Synthetic Products,In Cells or Tissue Sections
Tissue Sample
Fixation
Dehydration&Embedding
Sectioning
Staining
Special Staining
2
Inflammation and repair follow cell and tissue injury induced by various exogenous and endogenous stimuli.
Inflammation is a protective response that eliminates (., dilutes, destroys, or isolates) the cause of the injury (., microbes or toxins) and disposes of both the necrotic cells and tissues that occur as a result of the injury.
and Repair
3
Pathways of reparative responses after acute inflammatory injury .
炎滲液
4
The inflammatory response initiates the process that heals and reconstitutes the normal tissue.
During the reparative phase, the injured tissue is replaced by native parenchymal cells, or by filling up the defect with fibroblastic scar tissue, or both.
The e depends:
Restoration of normal structure and function
Scarring results
(1) tissue injury is transient or short-lived
(3) the tissue is capable of regeneration
(2) tissue destruction is small
the injury is extensive or occurs in tissues that do not regenerate.
5
( A ) Initial contact of cell with solid substrate .
( B ) Formation of bonds between cell surface receptors and cell adhesion ligands .
( C ) Cytoskeletal anization with progressive spreading of the cell on the substrate for increased attachment strength .
6
An abscess膿腫 is the e when an infection cannot be eliminated, the body "controls" the infection by creating a wall around it.
Inflammati