文档介绍：·50· Chinese Journal of Information on TCM
·制剂与工艺·
环糊精包合清脑醒神贴中挥发性成分的研究
王锐,王艳宏,吕邵娃,管庆霞,杨志欣,李永吉
(黑龙江中医药大学,黑龙江哈尔滨 150040)
摘要:目的研究清脑醒神贴中挥发性成分的包合工艺。方法以均匀设计试验法设计β-环糊精包合工艺,采
用气相色谱法测定包封率。优选多种高分子材料制备,浇铸制成贴片。结果完成了关键技术包合工艺的研究,确定
最佳工艺为:β-环糊精与药物最佳包合比例为 5∶1,80 ℃恒温水浴搅拌 60 min 进行包封。用浇铸法制备出新型凝
胶骨架型中药控释穴位贴片。结论本制备工艺科学合理,具有良好的开发应用前景。
关键词:清脑醒神贴;包合工艺;β-环糊精;均匀设计
DOI:.1005-
中图分类号: 文献标识码:A 文章编号:1005-5304(2010)11-0050-03
Study of Cyclodextrin Inclusion of ponents in Qingnaoxingshen Patch WANG Rui,
WANG Yan-hong, LV Shao-wa, et al (Heilongjiang University of Chinese Medicine, Harbin 150040, China)
Abstract:Objective To study the process of β-cyclodextrin (β-CD) inclusion techniques for volatile
components in Qingnaoxingshen patch. Methods Inclusion techniques were selected by screening on
uniform-design method, the content was identified by GC. Casting method was used to prepare into path.
Results The study of a key process technology pleted. The optimal technical conditions were as
follows:the ratio of β-CD and drug was 5∶1, temperature was 80 ℃, time was 60 min. Preparation of a
new type of gel-matrix controlled-release type of patches was estimated. Conclusion This method is
scientific and it may have a prosperous future.
Key words:Qingnaoxingshen patch;inclusion process;β-cyclodextrin;unif