文档介绍：农药学学报2011,13(3):221—227 Chinese Journal of Pesticide Science hap:// ·专论与综述· 植物乙酰乳酸合成酶抑制剂作用方式及机理研究进展于澄宇’,何蓓如(西北农林科技大学农学院,陕西杨凌712100) 摘要:以拟南芥Arabidopsis thaliana等植物为主要对象,系统评述了乙酰乳酸合成酶(ALS)抑制剂在作用靶标、选择性机制、毒性机理及化学杀雄作用等方面的研究进展。ALS是磺酰脲类、咪唑啉***类等多种除草剂的共同作用靶标,最新研究又发现苯磺隆、酰嘧磺隆等多种ALS抑制剂可作为敏感植物的化学杀雄剂。目前该研究领域的薄弱环节是ALS抑制剂的毒性机理,先后提出了支链氨基酸饥饿、核酸合成受阻、ALS底物积累、养分转运障碍、无氧呼吸等假说,但均未能被证实。借助高通量的代谢组学、转录组学、蛋白质组学检测技术将能够更全面地揭示ALS抑制剂的生理生化效应,为研究其毒性机理提供新证据。关键词:乙酰乳酸合成酶;除草剂;化学杀雄荆;作用机理;植物毒性 DOI:.1008- 中图分类号:; 文献标志码:A 文章编号:1008-7303(2011)03-0221-07 Research progress on themode andmechanism ofaction ofplant acetolactate synthase inhibitors YU Cheng—yu‘,HE Pei—ru (CollegeofAgronomy,Northwest A&F University,Yangling 712100,Shaanxi Province。China) Abstract:The research progress on the mechanism of chemicals inhibiting acetolactate synthase (ALS),including the target of inhibitors,selectivemechanism,phytotoxicity mechanism,and gametocidal acfivity on cmcifcrousplants was the target ofseveral herbicides, including sulfonylurea,imidazolinone,sulfonylamino-carbonyltriazolinone,triazolopyrimidine and pyrimidinylthio(oroxy)-,some ALS inhibiting—herbicides such as tribenuron· methyl and amidosulfuron were highlighted by theirgametocidal activity on susceptible , themechanism leading tophytotoxicity ofALS inhibitors not possibl