文档介绍：Chapter 5
Analysis and Design of Biochemical Reactors
Chapter 5 Analysis and Design of Biochemical Reactors
Concept of Design of Bioch. Reactors
Bioch. Reactors
Stir tank reactor
Cycle reactor
Loop reactor
Plug flow reactor
Bubble reactor
Multi-cascade reactor
Fluid flow reactor
Cycle pipe reactor
Full mix membrane reactor
Immobilized bio-disc
Leaching filter
Membrane reactor
Batch operation
Semi-Batch operation
Continual operation
Bio-block Reactors
Bio-membrane reactors
Plug flow pattern
Full mix pattern
Full mix pattern
Plug flow pattern
Diagram of Divers Enzymatic Reactors & Operations
参阅《生化反应动力学与反应器》P285-290
Batch operation
Continuous
Multi-cascade reactor
Fluid flow bed
Stir vessel—super-filter integration set
Multi-cascade semi-operation
Loop flow reactor
Coil membrane reactor
Packed bed
Cycle immobilized bed
Piping immobilized bed
Basic Equation for Design of Bio-Reaction
(1)Mass balance(Accumulatn is 0 under steady state)
Calculation of Mass balance for substrates and products
ponents /unit volume
=
ponents /unit volume
ponents /unit volume
+
+
Accumulation ponents /unit volume
Grown cells /unit volume
Accumulated cells /unit volume
Died cells /unit volume
Output cells /unit volume
Input cells /unit volume
=
+
+
+
Calculation of Mass balance for cells
(2)Energy balance (Heat balance )
In a definite time:
Input heat /unit time
Output heat /unit time
Reaction heat /unit time
Accumulated heat /unit time
=
+
+
(3) Momentum balance
It is usually negligible for bioreactors because of operation conducted under constant pressure.
In conclusion, each balance in the same model as follows:
Input = output + consumption +accumulation
Batch Stirring Tank Reactor( BSTR )
Calculation of the reaction time “ t ”
For BSTR, Calculation of mass balance
(5-5)
Quantity of substrate,mol
Effective volume in the reactor
The rate of ponents rs
=
—The accumulation rate ponents
Reac