文档介绍：收稿: 2005年 3月,收修改稿: 2005年 5月 3 通讯联系人 e2 mail :fengchao ***@mail. tjmu. edu. cn γ2分泌酶抑制剂研究进展鄢浩姜凤超 3 (华中科技大学同济医学院药学院武汉 430030 ) 摘要阿尔茨海默病(AD )是老年人常见的神经系统变性疾病。近来研究认为阿尔茨海默病的产生主要起因于β淀粉样蛋白(β2 amyloid , A β)在大脑内的沉积,而由γ2分泌酶切割β淀粉样前体蛋白产生的疏水性 A β 42是形成 A β的主要原因, γ2分泌酶是防治阿尔茨海默病很有潜力的靶点。本文就 A β的形成、γ2分泌酶的生物学研究以及目前γ2分泌酶抑制剂的研究进展作一综述。关键词阿尔茨海默病 β淀粉样蛋白 γ2分泌酶 γ2分泌酶抑制剂中图分类号:Q55 ;R971文献标识码:A文章编号:10052 281X (2006 )02Π 32 03552 08 Recent Advances in the Research of γ2 Secretase Inhibitors YanHao JiangFengchao 3 (School of Pharmacy , Tongji Medical College of Huazhong Science &Techology University , Wuhan 430030 , China ) Abstract Alzheimerπ s disease (AD )is a progressive neurodegenerative disorder in the elderly. The current hypothesis for the cause of this disease is that it is the result of aberrant production of β2 amyloid (A β)and plaque deposition in the brain. A β 42, less soluble and forming the ponent of the amyloid plaques , is generated via the cleavage of β2 amyloid protein precursor (β2 APP )by γ2 secretase , a key enzyme in the production of A β. Therefore γ2 secretase is potential target for the treatment of Alzheimerπ s disease. This reviewfocuses on the studies of the formation of A βand the biology of γ2 secretase , and the development of γ2 secretase inhibitors. Key words Alzheimerπ s disease ; β2 amyloid ; γ2 secretase ; γ2 secretase inhibitors 1 引言阿尔茨海默病(Alzheimerπ s disease , AD