文档介绍：中华血液学杂志2004年7月第25卷第7期Chin J Hematol,Joly 2004,yof 25, 417 ·论著. Ph染色体阳性成人急性淋巴细胞白血病患者预后相关因素分析刘世和秘营昌刘旭平薛艳萍王慧君卞寿庚王建祥[摘要7目的分析影响Ph'成人急性淋巴细胞白血病(aALL)患者生存的各种相关因素。方法综合分析31例Ph' aALL相关临床参数,观察生存期,并进行统计学分析。结果Ph' aAI,l,%临床上表现为年龄偏高,白细胞计数、幼稚细胞数高,血小板计数较低. 免疫分型诊断以(汤mmon型为主(%,23例中有19例),%(23例中有7例)协同表达髓系抗原,CD34-患者占56. 5写(23例中有13例)。%中位缓解期4个月,中位生存期8个月. Ph伴附加染色体异常占Ph阳性总数的42%,常见的附加染色体异常包括一7,十Ph,del(9)(pll-12), add/t(16) (pl3)等。Ph伴附加染色体异常组血小板计数显著低于单纯Ph+组(P=0. 012)和变异Ph 易位组(P=O. 001)。免疫分型研究显示CD34'患者组缓解期及生存期显著短于阴性组(缓解期分别为0和9个月,P=O. 024;生存期分别为6个月和12个月,P=O. 034),,Ph合并附加染色体异常与否和临床异质性无显著相关,CD34表达在Ph' aALL中是一个不良的预后因素【关键词】白血病,琳巴细胞,急性;成人;费城染色体;预后;抗原,CD34 Analysis of factors associated with prognosis in patients with Ph chromosome positive adult acute lympho- blasticleukemia LIUShi-he, MI Yng-chang, LIUXu-ping, XUEYan-ping, WANG Hui-jun, BIAN Shou-gang, WANG 1 is,一二tang. Institute of Hematology&Blood Diseases Hospital, CAMS &PUMC,Tianjin 300020,China Corresponding author; WANG Jiarraiang [Abstrac口。场active To investigate factors associated with survival of patients with Ph chromo- some positive adult acute lymphoblastic leukemia (aALI)in a period of 11 years. Methods All the clinical parameters of 31 Ph positive patients were statistically analyzed by SPSS software.