文档介绍：
锁阳固精丸中非法添加物枸橼酸西地那非的检出方法
[摘要] 目的：建立一种测定中成药锁阳固精丸中掺入化学药枸橼酸西地那非的检测方法。方法：采用高效液相色谱法，色谱柱C18（250 mm× mm，5 μm）， mol/L磷酸三乙***溶液-甲醇-乙***(58∶25∶17)为流动相；检测波长为290 nm， ml/min。结果：~ μg/ml浓度范围内线性关系良好，%，RSD= %。结论：本法操作简便，结果可靠，可用于锁阳固精丸中非法添加物枸橼酸西地那非的检测。
[关键词] 锁阳固精丸；枸橼酸西地那非；高效液相色谱
[中图分类号]R917 [文献标识码]A [文章编号]1673-7210（2008）04（b）-050-02
Determination method of sildenafil citrate added illegally in Suoyang Gujing Pills
TONG Shao-hui1,LI Na2
( Institute for Drug Control, Dandong 118002, China; 2. Dandong Traditional Chinese Medicine Hospital, Dandong 118000, China)
[Abstract] Objective: To set up a practical method for determination of sildenafil citrate in Suoyang Gujing : The C18 column(250 mm× mm,5 μm) was used, mobile phase was mol/L potassium triethylamine-methanol-acetonitrile(58∶25∶17), the detective wavelength was set at 290 nm,and the flow rate was ml/: The liner range of sildenafil citrate was ~ μg/ average recovery was % with RSD of %.Conclusion: The method is simple, can be used to determine sildenafil citrate in Suoyang Gujing Pills.
[Key word] Suoyang Gujing Pills; Sildenafil citrate; HPLC
锁阳固精丸是由锁阳、肉苁蓉、巴戟天等24味中药组成的壮阳类中药，具有温肾固精的功效。临床用于肾虚滑精，腰膝酸软，眩晕耳鸣，四肢无力等症。在日常的监督检查中，我们加大了对壮阳类中药中非