文档介绍：Causal Relationship of Histone Modifications and
Gene Expression Indicated by Variable Bayeasian
Network Methods
Xueye Duan, Hongde Liu*, Xiao Sun
State Key Laboratory of Bioelectronics
Southeast University
Nanjing, China
******@seu.. (Corresponding Author)
Abstract—Due to involvement in changing of chromatin Carlo (MCMC) and greedy-search (GS). Combination of two
structure, histone modifications are very important in regulation of these methods is used more practically.
for gene expression. Some attempts have been done to resolve the
relationship among histone modifications and gene expression. In In this paper, we draw out works for the
this study, four types of work methods, Maximum histone modifications and gene expression data with these four
weight spanning tree (MWST), K2, Markov Chain Monte Carlo methods on the same dataset. We assessed variable results for
(MCMC) and greedy-search(GS), are used to study causal different methods. In this way, we parison for the
relationships. On a same dataset, the four methods resulted in different methods and found certain supports from the known
different characteristics in causal relationships. MWST and relationship in current literature.
MCMC were fast, but they did not plete results, and
MCMC were not stable. The works had an influence on
II. METHOD
K2 and GS. In our t