文档介绍：Anticancer Effect of Gambogic Acid in Gastric Cancer Line SGC-7901
Ning ZHONG Dong JIANG,Shi-Ying ZHENG.
Department of Thoracocardiac Surgery, The Department of Cardio-Thoracic Surgery, The
First
First Affiliated Hospital of Suzhou
People’s Hospital of Kunshan, Jiangsu, 215300,
China University ,Suzhou 215006, Jiangsu Province,
China
Correspondence to: Dr. Shi-Ying Zheng, Telephone: +86-512-65263570 Syzheng88@
Abstract-We investigate the anticancer effect of a gastric carcinoma adenocarcinoma SGC-7901
traditional Chinese medicine gambogic acid (GA) nude mice xenografts. The increase of bax gene
in human gastric cancer line SGC-7901 and and the decrease of bc1-2 gene expressions were
further study the mechanism of apoptosis found by RT- inhibition of GA on human
induction of differential human gastric gastric cancer line SGC-7901 was confirmed. This
cancer line SGC-7901 were treated with GA at effect connects with the inducing apoptosis in
different doses and different times, the inhibitory SGC-7901 cells and the molecular mechanism
rates were detected by MTT assay. Apoptosis might be related to the reduction of expression of
induced by GA in SGC-7901 cells was observed by apoptosis-regulated gene bcl-2, and the
Annexin-V/PI doubling staining flow cytometry improvement of the expression of
assay. And T/C (%) was ch