文档介绍：Validating work-Based Objective Measure for
Helical Membrane Protein Structures
Jun Gao Zhijun Li
Department of Bioinformatics puter Science Department of Bioinformatics puter Science
University of the Sciences in Philadelphia University of the Sciences in Philadelphia
Philadelphia, USA Philadelphia, USA
Institute of Theoretical Chemistry Institute for Translational Medicine and Therapeutics
Shandong University University of the Pennsylvania
Jinan, P. R. China Philadelphia, USA
E-mail address: z.******@
Abstract— Computational structure prediction, including de A major challenge of membrane protein structure
novo and homology modeling, is an important tool for membrane prediction is to assemble individual helices into high-quality
protein studies. Developing an accurate scoring function that can tertiary structures [11]. Developing accurate scoring functions
be used for structure discrimination and assessment remains a to assess the quality of TM helical packing represents an
challenge. In our previous work, we have analyzed a set of high- essential step toward the goal of predicting membrane protein
resolution membrane protein structures using work structures. Traditionally, scoring functions developed from
approach developed in our lab and proposed such a scoring small-molecule data or soluble protein structures are adopted