文档介绍：MicroRNA Locus Expression Analysis
with ic Relationship Based on
MicroRNA Control from High
Throughput Sequencing Data
Li Guo1, Zuhong Lu1,2*
1 State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering,
Southeast University, Nanjing, 210096, China
2 Key Laboratory of Child Development and Learning Science of Ministry of Education, Southeast
University, Nanjing, 210096, China
* E-mail address: ******@seu.
Abstract- High throughput sequencing technology parison of miRNAs correlated with
is widely applied to discover and profile locus, miRNA group, and ic relationship,
microRNAs (miRNAs) to gain insights into the can reveal important insights into the biogenesis,
biogenesis and function of miRNAs. In the study, evolution, and function of miRNAs.
we developed an approach paring relative
expression levels of different miRNAs based on Keywords- microRNA (miRNA); expression analysis;
suitable endogenous miRNA control and their gene cluster; ic relationship
locus in the genome, miRNA group (such as
miRNA cluster and miRNA family), and I. INTRODUCTION
ic relationship between corresponding MicroRNAs (miRNAs) are small
precursor sequences. According to the approach, non-protein-coding RNAs that are involved in
we analyzed miR-17-92 cluster and miR-17 family post-transcriptional gene regulation by target