文档介绍：On-line Monitoring of Fed-batch Penicillin
Cultivation using Time-varying and Multivariate
Statistical Analysis
Yongsheng Qi,Pu Wang,Xunjin Gao,Xiuzhe Ghen
School of Electronic Information and Control Engineering
Beijing University of Technology
Beijing ,China
Email:******@.
Abstract—On-line monitoring of penicillin cultivation processes is analysis, monitoring and diagnostic approaches. These
crucial to the safe production of high-quality products. Multi- procedures are now being widely adopted by the batch
way ponent analysis(MPCA), a multivariate chemical processes.
projection method, has been widely used to monitor batch and The multi-way ponent analysis (MPCA)
fed-batch processes. However, when MPCA is used for on-line methods have been proven to be very efficient for analyzing
batch monitoring, the future behavior of each new batch must be historical data from past production and diagnosing operation
inferred up to the end of the batch operation at each time and the problems [3][4]. However, conventional MPCA proposed by
batch lengths must be equalized. This represents a major Nomikos and MacGregor [5][6] has the limitation that, when
ing because predicting the future observations without used for on-line monitoring, future values must be estimated
considering the dynamic relationships may distort the data
to