文档介绍：Christian Alzheimer
Molecular and
Cellular Biology
of Neuroprotection
in S
Molecular and Cellular Biology
of Neuroprotection in S
Molecular and Cellular Biology
of Neuroprotection in S
Edited by
Christian Alzheimer
Institute of Physiology
University of Kiel
Kiel, Germany
Kluwer Academic / Plenum Publishers
New York, Boston, Dordrecht, London, Moscow
Library of Congress Cataloging-in-Publication Data
CIP applied for but not received at time of publication.
Molecular and Cellular Biology of Neuroprotection in S
Edited by Christian Alzheimer
ISBN 0-306-47414-X
AEMB volume number: 513
©2002 Kluwer Academic / Plenum Publishers and Landes Bioscience
Kluwer Academic / Plenum Publishers
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Landes Bioscience
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No part of this book may be reproduced, stored in a retrieval system, or transmitted in any
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Printed in the United States of America.
PREFACE
The adult mammalian brain is not well equipped for self-repair. Although
neuronal loss reinstalls parts of the molecular machinery that is essential for neuronal
development, other factors and processes actively impede regeneration of the
damaged brain. Many therapeutic efforts thus aim to promote or inhibit these
endogenous pathways. In addition, more radical approaches appear on the horizon,
such as replacement of lost neurons with grafted tissue.
Neurorepair, however, is not the topic of this book. Here, we go one step back
in the sequence of events that lead eventually to the demise of a neuronal population.
This book focuses on the precious period when an initial damaging event evolves
into a vast loss of neurons. The