文档介绍：KDIGO CKD GL Public Review Summary Report

Stakeholder Section ments Developer’s Response
No.

Definition of CKD
ment 1 Albuminuria is rarely quantified in children and adolescents Thank you for ment. Non-
and even when measured does not pick up very high levels albumin proteinuria in Dent disease is
of low molecular weight proteins, as seen in the low an example of “Electrolyte and other
molecular weight proteinuria in children that appears to pre- abnormalities due to tubular disorders”
date Dent's Disease in adults. Unless the criteria are in Table 1, and is now mentioned
intended just for adults it would be advisable to add UP/C > explicitly in Table 2. Testing for non-
on a first morning urine to account for children with CKD. albumin proteinuria is included in
I think this was the subject of a similar discussion many .
years ago Andrew??
ment 2 1. UAE should also be used to define albuminuria. 1. We define increased albuminuria as
2. Should hematuria be a marker of kidney damage? In the AER (synonymous with UAE) in
patients with asymptomatic bacteriuria, hematuria is Tables 1-2.
common. 2. Thank you for ment. This
has been clarified in Tables 1 and 2.
ment 3 I believe that only the GFR below 60 ml/min is not evidence The choice of a GFR threshold <60
of CKD. mL/min/1,73m2 was driven by large
population studies examining
prognosis. Whilst we would agree that
in the absence of proteinuria and other
markers of kidney damage a GFR<60
is associated with less risk of adverse
e than in the presence of
proteinuria nevertheless there is still
an increased risk.
ment 4 Method of eGFR? Definition is based on GFR, not eGFR.
Methods for measurement and
estimation are discussed later.
ment 5 Urine sediment abnormalities and low level albuminuria too Thank you for ment. We
broad and will lead to many misdiagnosed with CKD. debated ments lon