文档介绍：对兔肾的乙酰胆碱能舒血管神经纤维功能存在性的探索
【摘要】目的在功能上探索肾内是否存在乙酰胆碱介导的舒血管神经纤维。方法用A兔的心血管系统为B兔的肾供血,刺激B兔的迷走神经;观察妥拉苏林、阿托品对A兔颈总动脉(PA)和动脉连通管血压(PL)的影响。结果刺激迷走神经,PL 和 PA均无变化;注射妥拉苏林,PL无立即改变,80秒后轻微上升;注射阿托品,PL无立即改变,1分钟后PL 和 PA呈周期性的同步的短暂下降。结论肾内不存在乙酰胆碱能舒血管纤维.
【关键词】乙酰胆碱能舒血管神经纤维搭桥模型妥拉苏林阿托品
Exploration for Cholinergic Vasoconstrictor Fiber in Kidney
LIU Jianbin LI Liying HUANG Xinyan PAN Wentao
Tutor: WANG Tinghuai
【Abstract】 Objective Explore whether there is cholinergic vasoconstrictor fiber in rabbit's kidney. Methods Make a model in which a kidney of a rabbit is supplied with blood by another rabbit. Then stimulate the left vagus nerve of the former rabbit. Inject tolazoline and atropine into the kidney one by one. Observe the blood pressure change mon carotid artery of the latter rabbit and at the arterial connecting tube(PA and PL). Results When vagus nerve is stimulated, PA and PL don't change. After injected tolazoline, PL doesn't increase slightly until 80 seconds later. When we inject atropine, PL remains for one minute and then decreases shortly and periodically together with PA. Conclusion Cholinergic vasoconstrictor fiber in rabbit's kidney is absent.
【Key Words】 Cholinergic vasoconstrictor fiber in kidney; Bridging model; Tolazoline; Atropine
1 前言
在人体内,对于一般内脏器官来说,都存在交感与副交感两种神经纤维的双重支配,其中交感神经兴奋,血管收缩;副交感兴奋则血管舒张,从而引起相应的生理反应。
目前,国内外对肾的神经支配的研究绝大多数集中于交感神经,这方面的报道也比较多;运用多种方法技术,已能确定多种神经、递质及受体的存在,而且对其